Treatment and research of skin healthcare based on nanosilver ion material technology
by Xu Yan; Xiaohui Wang
International Journal of Nanotechnology (IJNT), Vol. 17, No. 2/3/4/5/6, 2020

Abstract: Nanosilver materials are widely used in many fields such as medical, chemical, and biological, increasing the possibility of contact with humans, so it is necessary to pay attention to their biosafety. This paper aims to provide reference for the study of the toxic mechanism of nanosilver, provide a basis for establishing a standard nanosilver safety evaluation system, and understand the bactericidal effect and safety of skin disinfectant with silver ion as the main bactericidal ingredient. This paper firstly analyses the skin toxicity, respiratory toxicity and digestive toxicity of nanosilver. Secondly, it analyses the in vitro cytotoxicity and the interaction between intracellular nanosilver and biomacromolecules. Finally, it analyses the exposure to biosafety of nanosilver materials and nanosilver. The relationship between toxicity and silver ion is discussed. In this paper, laboratory observation was carried out using suspension quantitative bactericidal test and animal test method. The average killing rate for Staphylococcus aureus and Escherichia coli is 100.00%, and the average killing rate for Candida albicans is 99.9%. The disinfectant was sprayed with the disinfectant solution for 5 m in, and the average elimination rate of natural bacteria on the hands was 91.38%. The disinfectant has an acute oral toxicity test in mice of LD50 > 5000 mg/kg (body weight), which is an actual non-toxic grade. Therefore, the nanosilver ion skin disinfectant has a good killing effect on bacterial propagules and fungi, is a non-toxic substance, has no irritation to the skin and mucous membrane, and can be applied to skin management.

Online publication date: Wed, 28-Oct-2020

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Nanotechnology (IJNT):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com