Computational studies to explore the role of MSI associated DNA mismatch repair mechanisms in HNPCC through expression and interaction data Online publication date: Tue, 16-Feb-2021
by Sadhika Behl; Arushi Sharma; Prashanth Suravajhala; Tiratha Raj Singh
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 16, No. 4, 2020
Abstract: Microsatellite instability (MSI) is an error mechanism associated with DNA mismatch repair (MMR) system constituting a set of genes. If MMR fails, MSI may lead to various forms of cancers such as hereditary non polyposis colorectal cancer (HNPCC). In this study, we explored the gene expression and network data to reveal the significance of MSI in HNPCC. Genes and proteins were observed for their specific role in HNPCC with respect to MSI and MMR. Besides standard markers, few genes such as PMS1, TP53, MLH1, CHEK2, RFC3, LIG1, AURKA, CCND1, POLD1, HMGB1, ERCC1, ERCC2, PTGS2, and SLC19A1were identified as putative markers having significant contribution in the regulation of the mechanisms associated with MSI and MMR for HNPCC. Experimental validation of these genes will prove to be a promising outcome for further research and will aid in understanding of the disease.
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Bioinformatics Research and Applications (IJBRA):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email subs@inderscience.com
Our Blog 
Follow us on Twitter 
Visit us on Facebook