Pulsatile flow: micro-scale erythrocyte-platelet interaction
by Thakir AlMomani; Suleiman Bani Hani; Samer Awad; Mohammad Al-Abed; Hesham AlMomani; Mohammad Ababneh
International Journal of Biomedical Engineering and Technology (IJBET), Vol. 37, No. 2, 2021

Abstract: Platelet aggregation, activation, and adhesion on the blood vessel and implants result in the formation of the mural thrombi. Erythrocyte has shown to play a significant role in the aggregation process of platelets. A level-set sharp-interface immersed boundary method is employed to study the erythrocyte platelets interaction using a two-dimensional Cartesian co-ordinate system. Erythrocytes and platelets are treated as rigid non-deformed particles, where erythrocyte assumed to have an elliptical shape while platelet is assumed to have a discoid shape. Both steady and pulsatile flow regimes were employed with Reynolds number values equivalent to those find in the micro-blood vessels. Erythrocytes and platelets are transported under the forces induced by fluid and cell collision. The results indicated that platelets tend to show more interaction with erythrocytes for steady flow than those found in the pulsatile flow. Moreover, platelets tend to concentrate in the core region in the case of pulsatile flow.

Online publication date: Wed, 08-Dec-2021

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