Analysis of the combined estrogenic activity of plasticisers
by Hui Zhang; Shiqi Zhen; Zhaoying Tan; Chicheng Cao; Qi Zhang; Qi Ju
International Journal of Environment and Pollution (IJEP), Vol. 68, No. 1/2, 2020

Abstract: Several studies have reported that plastic additives exhibit estrogenic activity and may cause adverse effects on human health. However, existing risk assessment procedures lack the capability to accurately evaluate the combined effects of plastic additives. In this study, we performed E-screen assay to quantify estrogenic activities of single chemicals and their mixtures. We applied biomathematical regression models to simulate toxicity of four single substances. The best-fit for the dose-response relationships of individual compounds and their mixture were modelled using Weibull functions. The effects of the mixture were then estimated using three additive models, the CA, IA and the joint action models. Comparison of the model-predicted mixture effects with experimentally-determined results allows determination of the most representative model. Our results suggest that IA is the most representative and robust model to access the combined effects of the mixture, which provides reference data for health risk assessment of combined pollution of plasticisers.

Online publication date: Tue, 14-Dec-2021

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