A model for the roles of actin and myosin in adjustable preload tension and acute length adaptation
by S. Omid Komari; Adam P. Klausner; Paul H. Ratz; John E. Speich
International Journal of Computational Biology and Drug Design (IJCBDD), Vol. 16, No. 1, 2024

Abstract: Muscle mechanical behaviour is crucial in understanding bladder disorders. In detrusor smooth muscle (DSM), actin-myosin cross-bridges drive bladder contraction. Total tension comprises preload and active tensions. Studies suggest that actin-myosin cross-links are involved in adjustable preload stiffness (APS), which is characterised by a preload tension curve that can be shifted along the length axis as a function of strain and activation history. DSM displays length adaptation, with the active tension curve similarly shifting. Actin-myosin cross-bridges are also responsible for myogenic contractions in response to quick stretch of DSM strips and spontaneous rhythmic contractions (SRC) that may occur during bladder filling. Mechanical spring-dashpot models incorporating Kelvin/Voigt systems were developed to simulate active and preload length-tension curves, reflecting length adaptation and SRC history. Results highlight the influence of actin-myosin cross-bridge overlap and cross-links on dynamic length-tension relationships in DSM. This study offers insights into DSM mechanics, potentially advancing treatment for bladder disorders.

Online publication date: Tue, 02-Jul-2024

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