Assessment of the osteoblastic cell response to a zinc glass reinforced hydroxyapatite composite (Zn-GRHA)
by N. Sooraj Hussain, P.S. Gomes, M.H. Fernandes, M.A. Lopes, J.D. Santos
International Journal of Nano and Biomaterials (IJNBM), Vol. 2, No. 1/2/3/4/5, 2009

Abstract: Hydroxyapatite (HA), Ca₁₀(PO₄)₆(OH)₂ and tricalcium phosphate (TCP) bioceramics have been used as graft materials. However, optimal biological performance has not been established yet and zinc, being a biosafe, biocompatible element, could favour for specific osteoblastic cell response. Therefore, this paper investigates the preliminary results and potential impact of zinc glass reinforced hydroxyapatite (Zn-GRHA) on a human osteoblastic cell system. The biological behaviour of Zn-GRHA samples was assessed by confocal laser scanning microscopy, while material characterisation was performed by SEM-EDX and XRD analysis. Established cultures reported an increased proliferation and a confluent cell layer in some areas of the material surface at day two. Cells were spread all over the material surface and established multiple cell-to-cell interactions relying on prominent cytoplasmic processes. At day six, confluent cell layers were verified on the Zn-GRHA material's surface, reporting an improved biological response, compared to control (hydroxyapatite).

Online publication date: Sat, 08-Aug-2009

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