Expression of IFNg and TGFb1 genes can distinguish radiation workers from the normal population Online publication date: Fri, 27-Mar-2015
by Reza Fardid; Mohammad Taghi Bahreyni-Toossi; Abdolrahim Rezaee; Ariane Sadr-nabavi; Houshang Rafatpanah
International Journal of Low Radiation (IJLR), Vol. 9, No. 5/6, 2014
Abstract: Ionising radiation can cause different forms of DNA damage in living cells. Changes in biomarkers due to exposure to ionising radiation can be an appropriate tool for the immediate recognition of individuals exposed to radiation after a radiological accident or nuclear disaster. QPCR technique, as an approved method, was used for analysing the expression levels of sensitive genes following radiation exposure. Gene expression studies were performed on a group of 36 radiation workers and 36 matched-normal people without a history of radiation exposure. Mean gene expression values for control and irradiated groups were compared. There was significant difference between the mean gene expression of IFNg (p < 0.05), also significant difference was observed between the gene expression of TGFb1 (p < 0.05) in normal and irradiated groups. The logistic regression model is able to correctly identify 72.2% of irradiated samples (sensitivity) and 80.6% of normal samples (specificity).
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Low Radiation (IJLR):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email subs@inderscience.com
Our Blog 
Follow us on Twitter 
Visit us on Facebook