Title: Long non-coding RNAs in animal genomes: challenges and promises

Authors: Prashanth Suravajhala; Lingzhao Fang

Addresses: Department of Molecular Biology and Genetics, Center for Quantitative Genetics and Genomics, Aarhus University, Tjele, 8830, Denmark; Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, RJ, India ' Department of Molecular Biology and Genetics, Center for Quantitative Genetics and Genomics, Aarhus University, Tjele, 8830, Denmark

Abstract: Majority of the eukaryotic genes do not code for proteins, i.e., there are regions without coding potential. If they do not code, it was earlier supposed to be of disinterest as they wouldn't be associated with any disease. However, the last decade has seen advances in the field with certain (non-coding) RNA molecules transcribed; regulate expression of genes and further known to affect the transcription and cell cycle of organism. A class of such non-coding RNAs identified during the last decade is long non-coding RNAs (lncRNA) that are known to play a role in wide variety of diseases. We outline a few challenges and promises of lncRNAs specific to animal/livestock genomes that we could exploit in identifying their role in various diseases. For brevity, we have considered bovine/clinical mastitis to show an example.

Keywords: long non-coding RNAs; transcription; diseased genes.

DOI: 10.1504/IJBRA.2019.103787

International Journal of Bioinformatics Research and Applications, 2019 Vol.15 No.4, pp.347 - 358

Received: 16 Jul 2016
Accepted: 07 Oct 2017
Published online: 29 Nov 2019 *

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