Title: Assessment of drug-drug interactions and its associated factors in patients receiving second-line antitubercular drugs (MDR TB/XDR TB) in a tertiary care hospital in eastern India

Authors: P. Ansuman Abhisek; Priti Das; Shweta Supriya Pradhan; Geetanjali Panda; Srikanta Mohanty

Addresses: Department of Pharmacology, MKCG Medical College and Hospital, Berhampur, Odisha, India ' Department of Pharmacology, SCB Medical College and Hospital, Cuttack, Odisha, India ' Department of Pharmacology, MKCG Medical College and Hospital, Berhampur, Odisha, India ' Department of Pulmonary Medicine, SCB Medical College and Hospital, Cuttack, Odisha, India ' Department of Pharmacology, HITECH Medical College and Hospital, Bhubaneswar, Odisha, India

Abstract: This was a prospective, observational study conducted to assess prevalence of different spectrum of DDIs in MR/XDR TB patients by analyzing 42 prescriptions. DDIs were analysed by softwares like Lexicomp, Micromedex, and Drugs.com, Medscape.com. Only interactions of major/moderate severity were included in the potential DDIs analysis. Quantitative assessments were compared using one way ANOVA. Qualitative assessment of software was done manually by mere observation. Patients received 12.52 (±4.04) drugs during their total treatment period. Among 467 interactions observed, 34.04% were major, 50.10% moderate. All the patients had at least one potential DDI and 92.85% were exposed to at least one major potential DDI. Among the 'risk rating avoid combinations' (X) were 7.28%, 'modify regimen' (D) were 15.04%. Most DDIs were of moderate severity (50.10%) and the possible mechanism of DDI found was of pharmacodynamic in nature (49.76%). This study assists in understanding the utility of computer software-based programs to assess potential DDIs and the factors associated with them.

Keywords: prevalence; frequency; severity; risk; pharmacodynamic; Micromedex; Lexicomp; Drugs.com; Medscape.

DOI: 10.1504/IJMEI.2020.107092

International Journal of Medical Engineering and Informatics, 2020 Vol.12 No.3, pp.260 - 277

Received: 10 Oct 2017
Accepted: 28 Aug 2018
Published online: 04 May 2020 *

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