Title: Ameliorative effects of selenium nanoparticles on letrozole induced polycystic ovarian syndrome in adult rats

Authors: Maisra Azhar Butt; Asad Ullah; Mubin Mustafa Kiyani; Sarwat Jahan

Addresses: Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan ' Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan ' Department of Bioinformatics and Biotechnology, Faculty of Basic and Applied Sciences, International Islamic University, Islamabad, Pakistan ' Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan

Abstract: Selenium (Se) is an essential trace element playing vital role in the physiological processes. It was ignored as a therapeutic agent in the past, but in 1950s it was revealed that it must be obtained from diet as it cannot be produced by organisms. The present study was designed to investigate the anti-androgenic and metabolic effects of selenium nanoparticles (SeNPs) on letrozole induced PCOS using female rats. All rats were administered orally with letrozole (1 mg/kg) in CMC (0.5%) for 36 days. Rats were provided with metformin (2 mg/kg), Se-I (250 mg/kg), Se-II (500 mg/kg), SeNPs-I (50 mg/kg) and SeNPs-II (100 mg/kg) for 15 days. On 37th day animals were sacrificed and biochemical tests, antioxidants and histopathological analysis were performed. The results of the current study depict the anti-androgenic potentials of Se and SeNP for the treatment of PCOS that can be a new drug in the management of PCOS.

Keywords: selenium; selenium nanoparticles; biochemical test; histology.

DOI: 10.1504/IJBNN.2020.107184

International Journal of Biomedical Nanoscience and Nanotechnology, 2020 Vol.4 No.1/2, pp.49 - 69

Received: 22 Dec 2018
Accepted: 29 Apr 2019
Published online: 07 May 2020 *