Title: Study of silver nanoparticles activity against He-La cell lines

Authors: Shweta Rajawat; M.M. Malik

Addresses: Department of Physics, Maulana Azad National Institute of Technology, Bhopal (MP) 462003, India ' Department of Physics, Maulana Azad National Institute of Technology, Bhopal (MP) 462003, India

Abstract: In the present work, poly-dispersed silver nanoparticles (Ag NPs), using principles of green chemistry, are synthesised and their anti-cancer activity against He-La cell lines is studied. The synthesis method is easy, simple, environment friendly and does not require any sophisticated labs. One of the physical synthesis methods, electrolytic deposition technique with black tea leaf extract as capping agent, was designed to synthesise silver nanoparticles. Elemental analysis using X-ray patterns show synthesis of highly pure silver nanoparticles. Activity against cell lines was observed in a dose-dependent manner using MTT assay. The IC50 value of sample against He-La cervical cancer cell lines were obtained at 30-fold dilutions of concentration of 178 μg/ml.

Keywords: green technology; silver nanoparticles; He-La cervical cell lines; IC50 values; nanomanufacturing.

DOI: 10.1504/IJNM.2020.110383

International Journal of Nanomanufacturing, 2020 Vol.16 No.4, pp.312 - 321

Received: 17 Jan 2018
Accepted: 15 Feb 2019
Published online: 19 Oct 2020 *

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