Title: Study on the application of nanotube combined exercise rehabilitation therapy in the treatment of knee arthritis patients

Authors: Bo Chang

Addresses: Students' Affairs Division of Huainan United University, Huainan, 232038, Anhui, China

Abstract: Knee osteoarthritis (KOA) is a common chronic joint disease in clinical practice, and there is currently no effective cure. Among the many non-surgical therapies for KOA, exercise therapy as a safe and effective treatment has been accepted by more and more people. At present, more clinically applied and researched exercise therapies include strength training, aerobic training, neuromuscular training, proprioceptive neuromuscular promotion method, whole body vibration training, and its therapeutic effects include alleviating knee pain, enhancing lower limb muscle strength and stability to improve knee function. The current research has explored the action mechanism of exercise therapy for KOA from the perspective of molecular biology and physiology, but the specific action mechanisms of various kinds of exercise therapy and the intensity, time and frequency in clinical application need to be further studied. In this paper, titanium dioxide nanotube coatings were prepared by electrochemical anodisation, and the structure characterisation and electron microscope observation were performed. Materials with different nanotube pore sizes were prepared under different preparation conditions and their structural characteristics were compared. Then, bone marrow mesenchymal stem cells were cultured on the surface of titanium nanotubes, and their activities of adhesion, growth and differentiation were observed. The effects of nanotube structure on osteoblasts were compared on different nanostructure surfaces. Finally, it was found that the surface of the titanium nanotube material is suitable for bone marrow mesenchymal stem cells to adhere, grow, and promote their differentiation into osteoblasts. The surface of titanium nanotube materials with different pore sizes has different effects on bone marrow mesenchymal stem cells. When d = 30 nm, stem cells tend to adhere and have less morphology. As the pore diameter increases to 100 nm, the ability to adhere to cells decreases, and the morphology of the cells becomes longer and the osteogenesis ability is enhanced.

Keywords: titanium nanotubes; osteoarthritis; cell growth; knee; exercise therapy; stem cells; joint.

DOI: 10.1504/IJNT.2020.110725

International Journal of Nanotechnology, 2020 Vol.17 No.2/3/4/5/6, pp.393 - 410

Published online: 28 Oct 2020 *

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