Title: Anticandidal and antioxidant activity of silver and gold nanoparticles biosynthesised using matured areca nut husk extract

Authors: Bhavana Pradeep; Priyanka Hemba; Anusha Kunnathuli Jagadeesh; Chaitra Ganappa Ramakkanavar; Sneha Nayak; Chandrayan Vaman Rao

Addresses: Department of Biotechnology Engineering, NMAM Institute of Technology, Visvesvaraya Technological University, Nitte 574110, India ' Department of Biotechnology Engineering, NMAM Institute of Technology, Visvesvaraya Technological University, Nitte 574110, India ' Department of Biotechnology Engineering, NMAM Institute of Technology, Visvesvaraya Technological University, Nitte 574110, India ' Department of Biotechnology Engineering, NMAM Institute of Technology, Visvesvaraya Technological University, Nitte 574110, India ' Department of Biotechnology Engineering, NMAM Institute of Technology, Visvesvaraya Technological University, Nitte 574110, India ' Department of Biotechnology Engineering, NMAM Institute of Technology, Visvesvaraya Technological University, Nitte 574110, India

Abstract: The present work focuses on the biosynthesis of silver as well as gold nanoparticles using matured Areca catechu (areca nut) husk extract and study on their functional properties. Change in the colour of the extract from pale-yellow to orange and purple, surface plasmon resonance in the region of 400-450 nm and 500-550 nm, respectively indicated the formation of silver and gold nanoparticles. When subjected to the anticandidal test, it was found that the nanoparticles could inhibit the growth of Candida albicans, where an inhibition zone of 9 mm and 6 mm was observed for silver and gold nanoparticles respectively. It was found that silver and gold nanoparticles exhibit better antioxidant capacity than the husk extract. These antioxidant properties of nanoparticles can be used in the production of various pharmaceutical and cosmetic products. Using this approach, areca nut husk can be put into good use, which otherwise, is treated as waste.

Keywords: anticandidal activity; antioxidant activity; biosynthesis; Candida albicans; gold nanoparticles; matured areca nut husk extract; particle size distribution; phytochemicals; silver nanoparticles; zeta potential.

DOI: 10.1504/IJNP.2021.114897

International Journal of Nanoparticles, 2021 Vol.13 No.1, pp.21 - 32

Received: 19 Aug 2019
Accepted: 30 Apr 2020
Published online: 11 May 2021 *

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