Title: Neurotrophic factors combined with ordered collagen nano-modified materials in the recovery of exercise ability of patients with peripheral nerve transection

Authors: Yiming Gu; Chaoyang Yang

Addresses: Sports Department, Capital University of Economics and Business, Beijing, China ' Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, 100069 Beijing, China

Abstract: This study was to analyse the application of neurotrophic factor (NTF) combined with ordered collagen modified material (OCMM) (taking graphene oxide (GO) as example) modified nanofibre stent (NFS) in the recovery of exercise ability of patients with peripheral nerve transection (PNT). The graphene NFS was prepared by dissolving the graphite powder to prepare graphene nanomaterials by ultrasonic and centrifugal treatment methods. It showed that the NFS was successfully modified and had good mechanical properties, hydrophilicity, and biocompatibility. In addition, the nanofibre material (NFM) can effectively enhance the migration and proliferation of neuronal cells, thereby promoting nerve regeneration and exercise recovery in patients with nerve injury.

Keywords: neurotrophic factor; peripheral nerve transection; water contact angle; silk fibroin; nerve regeneration.

DOI: 10.1504/IJNT.2022.128957

International Journal of Nanotechnology, 2022 Vol.19 No.6/7/8/9/10/11, pp.790 - 804

Received: 30 Apr 2021
Accepted: 02 Jun 2021
Published online: 13 Feb 2023 *

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