Title: Influence of gold nanoclusters biomaterials combined with upper limb rehabilitation robot on patients with limb ischemic injury

Authors: Yan Zhai; Xiaobo Guo; Yong Zhang; Yongzheng He; Zhiqiang Li

Addresses: School of Mechanics Engineering, Anyang Institute of Technology, Anyang 455000, China ' School of Mechanics Engineering, Anyang Institute of Technology, Anyang 455000, China ' Scientific Research Office, Anyang Institute of Technology, Anyang 455000, China ' Company of XiangYu Medical, Neihuang 455000, China ' Company of XiangYu Medical, Neihuang 455000, China

Abstract: The reverse microemulsion was prepared and gold nanoparticles (AuNPs) were synthesised from it. Then, AuNC biomaterials were prepared by modifying folic acid with dendrimers, which were applied to patients with limb ischemic injury. The results showed that the spectra of AuNC synthesised by the two methods of water phase and oil phase were similar, and the spectra of AuNC synthesised before and after folic acid modification were also quite similar. The shoulder adduction scores (55.87 ± 4.07, 69.84 ± 3.87) and shoulder abduction scores (65.38 ± 5.21, 80.21 ± 4.13) of the experimental group after rehabilitation intervention for three and five weeks were significantly high, and those of control group was significantly higher than the blank group (P < 0.05). The arm supination score (40.2 ± 2.48) of the experimental group after rehabilitation intervention was significantly higher than that of the control group (31.44 ± 2.59) and the blank group (29.78 ± 2.76), and that of control group was significantly higher than the blank group (P < 0.05).

Keywords: gold nanoclusters; sodium borohydride; surfactants; ischemic injury; reverse microemulsion.

DOI: 10.1504/IJNT.2022.128958

International Journal of Nanotechnology, 2022 Vol.19 No.6/7/8/9/10/11, pp.805 - 821

Received: 30 Apr 2021
Accepted: 11 Jun 2021
Published online: 13 Feb 2023 *

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