Title: Computational study of the progression of Alzheimer's disease and changes in hippocampal theta rhythm activities due to beta-amyloid altered calcium dependent ionic channels

Authors: Akanksha Kaushik; Jyotsna Singh; Shilpa Mahajan

Addresses: CSE Department, The NorthCap University, Gurugram, India ' School of Technology and Management, NMIMS Chandigarh, India ' CSE Department, The NorthCap University, Gurugram, India

Abstract: Although, Amyloid beta (β-amyloid) and neurofibrillary tangles are the assay mark of Alzheimer's disease (AD), cognitive decline is best concerned with synaptic loss, rather than tangles or plaques. The pyramidal neurons in Hippocampus are highly affected by AD. Therefore, pyramidal neurons are prime focus in our study. Pyramidal neurons have extensively developed calcium signalling, a phenomenon that controls the neuronal rhythms desirable for memory processing and cognition, for regulating wide range of functions like controlling rhythmic activities, information processing and memory binding. The focus of our work is to inspect the impact of β-amyloid on calcium signalling and progression of AD through computational study.

Keywords: Alzheimer's disease; calcium signalling; pyramidal neurons; hippocampus.

DOI: 10.1504/IJMEI.2024.135686

International Journal of Medical Engineering and Informatics, 2024 Vol.16 No.1, pp.71 - 81

Received: 03 Jun 2021
Accepted: 07 Nov 2021
Published online: 22 Dec 2023 *

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