Title: Plaque rupture in stenotic coronary artery model: a numerical study

Authors: Md. Rakibuzzaman; Hyoung-Ho Kim; Sang-Ho Suh; A.K.M. Parvez Iqbal; Byoung-Kwon Lee; Hyuck Moon Kwon

Addresses: Department of Mechanical Engineering, International University of Business Agriculture and Technology, Dhaka 1230, Bangladesh ' School of Mechanical Material Convergence Engineering, Gyeongsang National University, Jinju 52725, South Korea ' School of Mechanical Engineering, Soongsil University, Seoul, 06978, South Korea ' Department of Mechanical Engineering, International University of Business Agriculture and Technology, Dhaka 1230, Bangladesh ' Department of Internal Medicine, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, South Korea ' Department of Internal Medicine, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, South Korea

Abstract: Atherosclerosis is a type of cardiovascular disease in which a wounded endothelial cell triggers a series of biochemical responses to repair the damage. As a mechanical response to the arterial wall, wall-shear-stress (WSS) is well investigated to become a significant contributing factor for atherogenesis and the development of atherosclerosis. This vascular wall behaviour could be utilised to predict plaque biomechanical instability and rupture susceptibility. Plaque has a significant function in causing blood vessel ruptures. This study used fluid-structure interaction (FSI) which is the combination of finite volume method (FVM) and finite element method (FEM) to investigate the deformable structure during internal fluid flow. Therefore, this particular approach has been implemented to investigate the features of stenosed with and without plaque ruptures under various situations. The von Misses stress (VMS) and WSS were determined. Results revealed that on both sides of arterial branch, higher WSS took place than below the plaque. Moreover, the highest intensity of VMS was roughly equivalent, when the distance between the plaque and the inner wall of the vessel was less than 65 μm, but the greater the distance, the greater the stress.

Keywords: coronary artery; plaque rapture; FSI analysis; von misses stress; VMS; wall-shear-stress; WSS.

DOI: 10.1504/IJBET.2024.136920

International Journal of Biomedical Engineering and Technology, 2024 Vol.44 No.2, pp.177 - 190

Received: 01 Oct 2022
Accepted: 06 Jan 2023
Published online: 29 Feb 2024 *

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