Title: Synthesis and characterisation of iron oxide nanoparticles with thymoquinone

Authors: Sheshadri S. Temkar; M. Tarun; Seema Tharannum; M.S. Dinesh

Addresses: Department of Biotechnology, PES University, Bangalore, Karnataka, 560085, India ' Department of Biotechnology, PES University, Bangalore, Karnataka, 560085, India ' Department of Biotechnology, Dayanand Sagar University, Bangalore Karnataka, 560079, India ' Department of Biotechnology, PES University, Bangalore, Karnataka, 560085, India

Abstract: Nigella sativa is a medicinal plant used for its antimicrobial properties. Thymoquinone (TQ), being the lead component of these plant seeds, exerts antibacterial, antifungal and antioxidant activity. It has also shown promising activity against cancer and inflammation through different modes of action. In recent developments for new applications in the field of medicine, nanotechnology has excelled as a very prominent and important field. Nanoparticles are generally in the dimension range of 1-100 nm. Iron oxide nanoparticles show enhanced antibacterial activity against gram-negative bacteria. The current research focuses on comparing the yield and stability of thymoquinone-synthesised iron oxide nanoparticles using different organic solvents, the benefits expressed by thymoquinone as a herbal drug, a novel approach to the green synthesis of iron oxide nanoparticles with thymoquinone, and testing for their stability, size and functional groups.

Keywords: iron oxide nanoparticles; Nigella sativa; thymoquinone (TQ); preparatory high-pressure liquid chromatography; FTIR analysis; zeta potential; DLS; dynamic light scattering.

DOI: 10.1504/IJNBM.2024.137667

International Journal of Nano and Biomaterials, 2024 Vol.10 No.3, pp.141 - 159

Received: 29 Mar 2023
Accepted: 20 Jun 2023
Published online: 02 Apr 2024 *

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