Title: Bacteriological profile of blood culture isolation and their antibiotic susceptibility pattern in BIMR Hospital, Gwalior, India

Authors: Santosh Kumar; Pranshu Sharma; Anju Goyal; Sujeet Mrityunjay; Nem Kumar Jain; Varsha Chauhan; Akshay Singh Sengar; Moti Lal

Addresses: Department of Biotechnology, ITM University, Gwalior, MP, India ' Department of Life Sciences, ITM University, Gwalior, MP, India ' Department of Microbiology, BIMR Hospital, Gwalior, MP, India ' Department of Life Sciences, ITM University, Gwalior, MP, India ' School of Pharmacy, ITM University, Gwalior, MP, India ' Department of Biotechnology, ITM University, Gwalior, MP, India ' Department of Food Technology, ITM University, Gwalior, MP, India ' Department of Biotechnology, ITM University, Gwalior, MP, India

Abstract: Blood stream infections can result in sepsis, a condition that can be fatal. Blood culture is the most effective way to diagnosis of sepsis. Multi-drug resistant (MDR) organisms have a higher probability to raise mortality risk of patients. Blood sample was collected and transferred into a bottle of blood culture and incubated for 5 days. The most typical organism isolated was Stenotrophonomas maltophilia (39.65%) which was followed by Staphylococcus aureus (20%) in terms of frequency. The most frequent isolate, Stenotrophomonas maltophilia, was 100% sensitive to Chloramphenicol, 95.65% to Trimethoprim-sulfamethoxazole and 86.95% sensitive to Levofloxacin. Daptomycin, vancomycin and linezolid showed 100% sensitivity against all identified gram positive bacilli (GPC). According to the current study, the most prevalent isolates from blood cultures were stenotrophomonas maltophilia and staphylococcus aureus, which is predominant organisms causing septicemia. Stenotrophomonas maltophilia, had greater susceptibility to chloramphenicol, trimethoprim-sulfamethoxazole and levofloxacin. Staphylococcus aureus, showed higher sensitivity to daptomycin, vancomycin, linezolid.

Keywords: multi-drug resistant; MDR; septicaemia; blood culture; blood-stream infections; stenotrophomonas maltophilia; antibiotic susceptibility.

DOI: 10.1504/IJBT.2023.138712

International Journal of Biotechnology, 2023 Vol.14 No.4, pp.293 - 302

Received: 23 Aug 2022
Accepted: 03 Jul 2023
Published online: 29 May 2024 *

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