Title: Development of an anti-microbial starch-based polymer film embedded with silver nanoparticles by green synthesis from tea extract: a potential low cost wound dressing for rural population of developing countries

Authors: Sambuddha Dinda; Anuradha B. Patil; Sumati Annigeri Hogade; Abhishek Bansal

Addresses: Department of Biochemistry, J.N. Medical College, KLE University, Belagavi, 590010, India ' Department of Biochemistry, J.N. Medical College, KLE University, Belagavi, 590010, India ' Department of Microbiology, J.N. Medical College, KLE University, Belagavi, 590010, India ' Department of Biochemistry, J.N. Medical College, KLE University, Belagavi, 590010, India

Abstract: Wound infection is a major cause of morbidity and mortality as treatment of large wound surface with prevention of infection is a major challenge. We developed a simple method to fabricate a low-cost anti-microbial starch-based polymer film embedded with silver nanoparticles (Ag-NP) generated via green synthesis from tea extract with readily available ingredients. Fabricated Ag-NP was characterised by UV-visible (UV-vis) spectroscopy (peak at 436 nm), transmission electron microscopy (diameter of 20.6 ± 11.8 nm), zeta potential (-18 mV) and X-ray diffraction study. The tea derived organic molecules in Ag-NP were confirmed by Fourier-transform infrared (FTIR) spectroscopy. The anti-microbial efficacy of the polymer embedded Ag-NP showed significant zone of inhibition against both gram-positive Staph aureus (22 ± 1.6 mm) and gram negative Pseudomona aeruginosa (16 ± 1.4 mm). This study showed anti-microbial efficacy of a low-cost starch-based polymer film containing Ag-NP with anti-oxidant biomolecules of green tea which can be easily fabricated and used for wound dressing.

Keywords: silver nanoparticle; green synthesis; green tea; starch-based polymer; anti-microbial effect.

DOI: 10.1504/IJBNN.2024.139295

International Journal of Biomedical Nanoscience and Nanotechnology, 2024 Vol.5 No.1, pp.1 - 14

Received: 19 Jul 2021
Accepted: 05 Apr 2022
Published online: 01 Jul 2024 *

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