Title: A kernelised fuzzy-Support Vector Machine CAD system for the diagnosis of lung cancer from tissue images

Authors: Walker H. Land, Daniel W. McKee, Tatyana Zhukov, Dansheng Song, Wei Qian

Addresses: Department of Bioengineering, Binghamton University, Binghamton, NY, 13903-6000, USA. ' Department of Mathematics and Computer and Information Sciences, Mansfield University, Mansfield, PA, 16933, USA. ' Department of Interdisciplinary Oncology, Colleges of Medicine and H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, 33612, USA. ' Department of Interdisciplinary Oncology, Colleges of Medicine and H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, 33612, USA. ' Department of Interdisciplinary Oncology, Colleges of Medicine and H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, 33612, USA

Abstract: This research describes a non-interactive process that applies several forms of computational intelligence to classifying biopsy lung tissue samples. Three types of lung cancer evaluated (squamous cell carcinoma, adenocarcinoma, and bronchioalveolar carcinoma) together account for 65–70% of diagnoses. Accuracy achieved supports hypothesis that an accurate predictive model is generated from training images, and performance achieved is an accurate baseline for the process|s potential scaling to larger datasets. Feature vector performance is good or better than Thiran and Macq|s in every case. Except bronchioalveolar carcinomas, each individual cancer classification task experienced improvement, with two groupings showing nearly 20% classification accuracy.

Keywords: computer-aided diagnosis; CAD; lung cancer; segmentation; feature selection; classification; microscopy images; kernel methods; support vector machines; fuzzy SVM; computational intelligence; biopsy lung tissue samples; cancer diagnosis.

DOI: 10.1504/IJFIPM.2008.018291

International Journal of Functional Informatics and Personalised Medicine, 2008 Vol.1 No.1, pp.26 - 52

Published online: 14 May 2008 *