Title: Synthesis of simplified human Growth Hormone secretion mechanism on FPGAs

Authors: Nazeih M. Botros, Yonglian Wang

Addresses: Department of Electrical and Computer Engineering, Southern Illinois University, Carbondale, IL 62901-6603, USA. ' Department of Electrical and Computer Engineering, Southern Illinois University, Carbondale, IL 62901-6603, USA

Abstract: In this paper, we present a simulation and hardware realisation on a compact electronic chip of a simplified growth hormone secretion mechanism. After realisation, the chip operates as a stand-alone device that mimics the function of the mechanism. The chip can be implemented to explore the function of the mechanism. To simulate the mechanism, a mathematical model has been developed. Four hormones have been considered, Growth Hormone (GH), Growth Hormone Releasing Hormone (GHRH), Somatotropin Release-Inhibiting Factor (SRIF) and Insulin like Growth Factor (IGF-1). After realisation, the chip is tested. The chip behaves identically to the operation of the simulated mechanism.

Keywords: human growth hormone; CAD; computer aided design; personalised medicine; HDL; hardware description language; RTL; register transfer level; hormone secretion; simulation; secretion mechanisms; mathematical modelling; field-programmable gate arrays; FPGA; electronic chips.

DOI: 10.1504/IJFIPM.2009.022839

International Journal of Functional Informatics and Personalised Medicine, 2009 Vol.2 No.1, pp.89 - 103

Published online: 27 Jan 2009 *

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