Title: Impact of feeding flaxseed oil on delaying the development of osteoporosis in ovariectomised diabetic rats

Authors: M. Elwassef, M. Anwar, M. Harvi, M.M. Abd El-Moneim, G.S. EL-Saeed, S.I. Salem, H. Wafay

Addresses: Department of Medical Biochemistry, Division of Medical Research, National Research Center, Cairo, Egypt. ' Department of Medical Biochemistry, Division of Medical Research, National Research Center, Cairo, Egypt. ' Department of Medical Biochemistry, Division of Medical Research, National Research Center, Cairo, Egypt. ' Department of Medical Biochemistry, Division of Medical Research, National Research Center, Cairo, Egypt. ' Department of Medical Biochemistry, Division of Medical Research, National Research Center, Cairo, Egypt. ' Department of Medical Biochemistry, Division of Medical Research, National Research Center, Cairo, Egypt. ' Department of Medical Biochemistry, Division of Medical Research, National Research Center, Cairo, Egypt

Abstract: This work is aimed to study the effect of diabetes on bone health and to evaluate the impact of feeding flaxseed oil on delaying osteoporosis. About 70 female albino rats were included; 30 were ovariectomised (ovx). Experimental diabetes was induced. Rats were classified in groups as control, sham, diabetic, diabetic received flaxseed oil in the diet, ovx, ovx-diabetic and ovx-diabetic received flaxseed oil in the diet. After two months, urine and blood samples were collected. Serum IGF-1 and osteocalcin were increased in ovx and diabetic ovx groups; their lowest levels were detected in the diabetic group. Upon adding flaxseed oil, their mean values were normalised. Urinary deoxypyridinoline was increased in diabetic group; the level was decreased as rats received flaxseed oil. Bone mineral density and content in diabetic group were reduced and normalised after receiving flaxseed oil. So, diabetes has more pronounced effect on bone health than ovariectomy, and flaxseed oil has beneficial effect on the prevention of osteoporosis.

Keywords: osteoporosis; diabetes; flaxseed oil; bone health; albino rats; ovariectomy.

DOI: 10.1504/IJFSNPH.2009.029284

International Journal of Food Safety, Nutrition and Public Health, 2009 Vol.2 No.2, pp.189 - 201

Published online: 18 Nov 2009 *

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