Title: Effect of pH on morphology, size and composition of calcium phosphate phase obtained in wet chemical

Authors: Sahebali Manafi, Sedigheh Joughehdoust, Seyyed Hossein Badiee

Addresses: Islamic Azad University Shahrood Branch and Young Research Club (YRC), P.O. Box 36155-163, Shahrood, Iran. ' Islamic Azad University Shahrood Branch and Young Research Club (YRC), P.O. Box 36155-163, Shahrood, Iran. ' Islamic Azad University Shahrood Branch and Young Research Club (YRC), P.O. Box 36155-163, Shahrood, Iran

Abstract: In the present work, the effect of pH of Ca(NO₃)₂.4H₂O and (NH₄)2HPO₄ primary solutions as the beginning materials in synthesis of a calcium phosphate phase, was examined. So, we investigated the wet chemical reactions in solution at ambient temperature by a sonochemical process aimed at hydroxyapatite synthesis. The results revealed that by reducing the pH of the systems, the probability of obtaining hydroxyapatite phase will be decreased and a noticeable reduction in size of particles will be seen. The tendency of particles is to grow along a preferable direction in pH = 4.2, but this tendency will disappear in lower and higher pHs. The results indicate that one-step synthesis of HA nanoparticles can be possible in aqueous solution using ultrasonic irradiation. Indeed, it will be favourable to obtain composition with a little difference from stoichiometric hydroxyapatite, which has very small particles in nanoscale, with considering biodegradation of bone cements and tissue engineering scaffolds.

Keywords: hydroxyapatite synthesis; sonochemical; biomaterials; nanotechnology; morphology; wet chemical synthesis; calcium phosphate; nanoparticles; ultrasonic irradiation; biodegradation; bone cements; tissue engineering.

DOI: 10.1504/IJNM.2010.029934

International Journal of Nanomanufacturing, 2010 Vol.5 No.1/2, pp.169 - 178

Published online: 03 Dec 2009 *

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