Title: Scanning probe recognition microscopy investigation of neural cell prosthetic properties

Authors: Virginia M. Ayres, Qian Chen, Yuan Fan, Dexter A. Flowers, Sally A. Meiners, Ijaz Ahmed, Roberto Delgado-Rivera

Addresses: Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA. ' Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA. ' Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA. ' Department of Electrical and Computer Engineering, Wayne State University, 5050 Anthony Wayne Drive, Detroit, MI 48202, USA. ' University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA. ' University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA. ' Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA

Abstract: Scanning probe recognition microscopy (SPRM) with auto-tracking of individual nanofibres is used for investigation of the key nanoscale properties of polyamide a nanofibrillar matrix that promotes more in vivo-like forms and functions for cultured cells. Both unmodified and fibroblast growth factor-2-modified nanofibres are considered. The contributions of nanofibrillar matrix elasticity and surface roughness to cellular behaviour are examined.

Keywords: scanning probe recognition microscopy; SPRM; adaptive scanning; basement membrane; electrospun nanofibres; fibroblast growth factor-2; FGF-2; elasticity; surface roughness; polyamide nanofibres; nanofibrillar matrix; cultured cells; cellular behaviour; computer vision; pattern recognition; signal processing; adaptive learning; prediction; tissue scaffolds; tissue engineering; neural cell prosthetics; nanotechnology; bioengineering.

DOI: 10.1504/IJNM.2010.034790

International Journal of Nanomanufacturing, 2010 Vol.6 No.1/2/3/4, pp.279 - 290

Published online: 22 Aug 2010 *

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