Title: Detecting slow-translating regions in E.coli

Authors: Lalit Ponnala

Addresses: Computational Biology Service Unit, Cornell University, Ithaca, NY 14853, USA

Abstract: We present an application of the spatial scan statistic to identifying clusters of slow-translating codons in E.coli. We use an estimate of the time taken to process each codon based on the availability of transfer RNA. We analyse our findings using experimental measurements, and provide support for a well-known hypothesis related to the process of protein production.

Keywords: transfer RNA; slow-translating codons; spatial scan; likelihood; E. coli; Escherichia coli; mRNA; protein production; bioinformatics.

DOI: 10.1504/IJBRA.2010.037990

International Journal of Bioinformatics Research and Applications, 2010 Vol.6 No.5, pp.522 - 530

Received: 03 Sep 2009
Accepted: 13 Apr 2010
Published online: 07 Jan 2011 *

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