Title: Screening SNPs residing in the microRNA-binding sites of Hepatocellular Carcinoma related genes

Authors: Jun Ding, Yuzhen Gao, Yan He, Yifeng Zhou, Moli Huang, Haiyan Liu

Addresses: Laboratory of Cellular and Molecular Tumor Immunology, Tang Chung Ying Blood Research Center, Suzhou 215123, China. ' Laboratory of Cellular and Molecular Tumor Immunology, Tang Chung Ying Blood Research Center, Suzhou 215123, China. ' Laboratory of Cellular and Molecular Tumor Immunology, Tang Chung Ying Blood Research Center, Suzhou 215123, China. ' Laboratory of Cellular and Molecular Tumor Immunology, Tang Chung Ying Blood Research Center, Suzhou 215123, China. ' Center for Systems Biology, Medical College, Soochow University, Suzhou 215123, China. ' Laboratory of Cellular and Molecular Tumor Immunology, Tang Chung Ying Blood Research Center, Medical College of Soochow University, Suzhou 215123, China

Abstract: Single nucleotide polymorphisms located at miRNA-binding sites are likely to affect the expression of the miRNA targets and may contribute to the susceptibility of humans to common diseases. Here we selected 289 candidate Hepatocellular Carcinoma (HCC) related genes according to the existing literature and database. We identified putative miRNA-binding sites of 52 genes by specialised algorithms, screened SNPs in the 3′-UTRs of 50 genes. Using BLAST program, we identified 5 genes that had SNPs in the regions of miRNA-binding sites, one of which is confirmed in another published study. We propose these SNPs for further investigations in case-control association studies.

Keywords: HCC genes; hepatocellular carcinoma; SNPs; single nucleotide polymorphisms; miRNA binding sites; common diseases.

DOI: 10.1504/IJDMB.2011.038574

International Journal of Data Mining and Bioinformatics, 2011 Vol.5 No.1, pp.1 - 21

Received: 19 Jan 2009
Accepted: 06 May 2009
Published online: 24 Jan 2015 *

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