Title: Experimental research on cell configuration control with micro-fluid

Authors: Qin Zhang; Weijun Huang; Wuchen Lei; Gang Su; Hisayuki Aoyama

Addresses: School of Mechanical and Automotive Engineering, South China University of Technology, Tianhe District, Guangzhou 510641, China ' School of Mechanical and Automotive Engineering, South China University of Technology, Tianhe District, Guangzhou 510641, China ' School of Mechanical and Automotive Engineering, South China University of Technology, Tianhe District, Guangzhou 510641, China ' School of Mechanical and Automotive Engineering, South China University of Technology, Tianhe District, Guangzhou 510641, China ' Department of Mechanical Engineering and Intelligent Systems, University of Electro-Communications, Chofu, Tokyo 182-8585, Japan

Abstract: Configuration (position and orientation) control is an important issue in the micromanipulation of cells. A non-contact method based on micro-fluid for cell configuration control is presented in this paper. A cell is positioned by the balanced pressure of a pair of lined micro-fluids from two tiny tubes. The orientation control is achieved by rotating the cell in a swirl caused by a pair of parallel opposite micro-fluids from the two tubes. With fluctuant micro-fluids generated by pulsating jetting, cell orientation can be controlled more precisely. The method is valid for cells of different shapes and sizes. The effectiveness of the proposed non-contact method for cell configuration control was verified by experiments.

Keywords: cell micromanipulation; microfluids; cell configuration control; swirl; pulsating jetting; non-contact; orientation control; cells.

DOI: 10.1504/IJNM.2014.062976

International Journal of Nanomanufacturing, 2014 Vol.10 No.4, pp.358 - 370

Received: 15 May 2012
Accepted: 21 Mar 2013
Published online: 24 Jul 2014 *

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