Title: Cost effectiveness analysis of parenteral nutrition therapies among hospitalised patients: multi-chamber bag system vs. compounding

Authors: Frank Xiaoqing Liu; Marc Botteman; Dipen A. Patel; Mark H. DeLegge; Catherine J. Mercaldi; Robin S. Turpin

Addresses: Baxter Healthcare Corporation, One Baxter Parkway, Deerfield, IL 60015, USA ' Pharmerit International, 4350 East West Highway, Suite 430, Bethesda, MD 20814, USA ' Pharmerit International, 4350 East West Highway, Suite 430, Bethesda, MD 20814, USA ' Baxter Healthcare Corporation, One Baxter Parkway, Deerfield, IL 60015, USA ' United BioSource Corp., 7101 Wisconsin Ave, Suite 600, Bethesda, MD 20814, USA ' Takeda Pharmaceuticals USA, Inc., One Takeda Parkway, Deerfield, IL 60015, USA

Abstract: Parenteral nutrition (PN) prepared by different methods may be associated with diverse health outcomes and treatment costs. This study used decision analysis techniques to compare the estimated costs of multi-chamber bag (MCB) PN vs. compounded PN in Canadian hospitalised patients in terms of costs and survival rates from the perspective of hospital decision makers. Model inputs were either estimated using the US Premier Perspective™ hospital database and applied to Canadian hospitalised patients or obtained from published literature. Univariate and probabilistic sensitivity analyses were conducted to test the robustness of study results. Compared to compounded PN, MCB PN was estimated to be associated with better outcomes in terms of bacterial infections, including BSI, and patient survival, with lower total hospitalisation costs per patient.

Keywords: cost effectiveness; parenteral nutrition; compounding; multi-chamber bag; hospitalised patients; Canada; survival rates; bacterial infections; hospitalisation costs; patient survival.

DOI: 10.1504/IJHTM.2014.064246

International Journal of Healthcare Technology and Management, 2014 Vol.14 No.3, pp.176 - 193

Received: 21 Sep 2012
Accepted: 24 Aug 2013
Published online: 30 Aug 2014 *

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