Title: Properties of metal oxide nanoparticles prepared by plasma discharge in water with ultrasonic cavitation

Authors: A.V. Ivanov; V.N. Nikiforov; S.V. Shevchenko; V.Yu. Timoshenko; V.V. Pryadun; N.A. Bulychev; A.B. Bychenko; M.A. Kazaryan

Addresses: N.N. Blokhin Russian Cancer Research Center, Russian Ministry of Health, Moscow, 115478, Russia ' Physics Department, M.V. Lomonosov Moscow State University, Moscow, 119991, Russia ' Physics Department, M.V. Lomonosov Moscow State University, Moscow, 119991, Russia ' Physics Department, M.V. Lomonosov Moscow State University, Moscow, 119991, Russia; P.N. Lebedev Physical Institute, Russian Academy of Sciences, Leninsky avenue, 53, Moscow, 119991, Russia ' Physics Department, M.V. Lomonosov Moscow State University, Moscow, 119991, Russia ' P.N. Lebedev Physical Institute, Russian Academy of Sciences, Leninsky avenue, 53, Moscow, 119991, Russia ' Chumakov Institute of Poliomyelitis and Viral Encephalitis, Moscow Region 142782, Russia ' P.N. Lebedev Physical Institute, Russian Academy of Sciences, Leninsky avenue, 53, Moscow, 119991, Russia

Abstract: Acoustic plasma discharge and cavitation in aqueous solutions were used to prepare metal oxide nanoparticles (NPs) based on tungsten, copper, iron and zinc. It was found that ultrasonic cavitation during the NP formation influenced strongly the size and physical properties of NPs, which were measured by means of the electron microscopy, dynamic light scattering (DLS) and photoluminescence (PL) techniques. In vitro studies did not reveal cytotoxicity of the NPs for concentration of up to 0.2 mg/mL and exposure time for one week. The obtained results indicate good prospects of the prepared NPs for biomedical applications in the PL diagnostics of cancer and magnetic hyperthermia.

Keywords: nanotechnology; ultrasound cavitation; metal oxides; cytotoxicity; metal oxide nanoparticles; acoustic plasma discharge; water; aqueous solutions; tungsten; copper; iron; zinc; biomedical applications; photoluminescence diagnostics; cancer diagnosis; magnetic hyperthermia.

DOI: 10.1504/IJNT.2017.083437

International Journal of Nanotechnology, 2017 Vol.14 No.7/8, pp.618 - 626

Published online: 30 Mar 2017 *

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