Title: Magnetically sensitive nanoparticles for magnetically controlled thermochemotherapy

Authors: V.N. Nikiforov; A.V. Ivanov; N.A. Brusentsov; T.S. Gendler; V.Yu. Irkhin

Addresses: Physics Department, M.V. Lomonosov Moscow State University, Moscow, 119991, Russia ' N.N. Blokhin Russian Cancer Research Center, Russian Ministry of Health, Moscow, 115478, Russia ' N.N. Blokhin Russian Cancer Research Center, Russian Ministry of Health, Moscow, 115478, Russia ' United Institute of the Earth Physics, RAS, Moscow, 123810, Russia ' Institute of Metal Physics, RAS, Ekaterinburg, 620990, Russia

Abstract: The water-based magnetite Fe₃O₄, maghemite γ-Fe₂O₃, Gd-substituted ferrites Fe[Gd_xFe_2−x]O₄, Ni-Cu alloy particles suspensions and dextran-ferrite (DF) solutions were prepared for the magnetically controlled thermochemotherapy (MCT). The temperature elevation prepared nanoparticles in AC magnetic field (0.88 MHz, 7.3 kA/m, 0.15 kW) and their toxicity were characterised. The results are in a good agreement with physical and chemical properties observed by in vitro measurements. The moment and Curie temperature of magnetic nanoparticles are obtained. The corresponding models of magnetic structure for magnetite, maghemite and Gd-doped ferrites are discussed.

Keywords: nanotechnology; magnetite; maghemite; magnetic nanoparticles; magnetic properties; AC magnetic field; Gd-substituted ferrites; gadolinium; toxicity; hyperthermia; biological properties; magnetically controlled thermochemotherapy; MCT; iron oxides; nickel alloys; copper; cancer therapy.

DOI: 10.1504/IJNT.2017.083439

International Journal of Nanotechnology, 2017 Vol.14 No.7/8, pp.646 - 653

Published online: 30 Mar 2017 *

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