Title: In vitro cytotoxicity and antibacterial studies of ruthenium(II) DMSO complexes with S-allyldithiocarbazate
Authors: Selvakumar Ponnusamy; Narayanasamy Ramasamy
Addresses: Department of Chemistry, SVS College of Engineering, JP Nagar, Arasampalayam, Myleripalayam via, Coimbatore-641014, India ' Department of Chemistry, Coimbatore Institute of Technology, Civil aerodrome post, Coimbatore-641014, India
Abstract: The ruthenium(II) DMSO complexes with formula [RuCl(DMSO)3L1](1) and [RuCl(DMSO)3L2](2) had been synthesised. The newly synthesised complexes are characterised by elemental analysis, UV-VIS, FT-IR, NMR and ESI-MS spectroscopy. The spectral and analytical data of the complexes 1 and 2 supports well with the molecular formulae proposed. The in vitro cytotoxicity of these complexes evaluated using MTT assay indicate that the above complexes are more toxic against Hela cervical cancer cell line, but significantly less toxic against the normal Vero cell line. Furthermore, the antibacterial activity of the complexes 1 and 2 against S.aureus and E.Coli had also been tested and compared with standard streptomycin.
Keywords: ruthenium(II) complexes; S-allyl dithiocarbazate; cytotoxicity and antibacterial activity.
DOI: 10.1504/IJMPT.2017.084958
International Journal of Materials and Product Technology, 2017 Vol.55 No.1/2/3, pp.142 - 155
Received: 17 May 2016
Accepted: 25 Nov 2016
Published online: 09 Jul 2017 *