Computational identification of personal genetic variants in an identical twin sisters' family
by Ruoxian Huang; Ruoya Huang; Yongsheng Bai
International Journal of Computational Biology and Drug Design (IJCBDD), Vol. 15, No. 2, 2022

Abstract: Nowadays, scientists still have a limited understanding of how much genetic variation exists between identical twins. This study aims to analyse genotypic differences between identical twins and annotate the functional variants. We employed the 23andMe genotyping service to compare the genomes of twin sisters and their family members. With 162,400 SNPs genotyped at the autosomes, we found that there were 64,083 (10.26%) differences between one of the twins and their sibling brothers, while only 2530 differences (0.41%) existed between twin sisters. In total, among the 1974 nonsynonymous variants genotyped, excluding 'no calls,' only 17 shared nonsynonymous pathogenic variants between twin sisters were identified. The 16 pathogenic variants harboured genes are enriched with six significant terms associated with liver function and metabolic pathways. Our research could provide insight for physicians conducting studies related to genetic variations and personalised treatment of genetic disorders of identical twins.

Online publication date: Wed, 16-Nov-2022

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Computational Biology and Drug Design (IJCBDD):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com