Monitoring optical responses and physiological status of human skin in vivo with diffuse reflectance difference spectroscopy Online publication date: Fri, 31-Mar-2023
by Jung Y. Huang; Jyun Ying Chen
International Journal of Biomedical Engineering and Technology (IJBET), Vol. 41, No. 3, 2023
Abstract: Fourier-transform visible-near infrared spectroscopy was applied to analyse diffuse reflectance from human skin perturbed with three skin-agitating methods. Principal component analysis (PCA) was applied to deduce three characteristic spectral responses of human skin. Based on Monte-Carlo multilayer simulation, the responses can be attributed to changes in light scattering and haemoglobin and melanin content. The eigenspectra form a basis for resolving the optical responses of human skin from diffuse reflectance difference spectra measured at different time points after the skin tissue is mechanically stressed. We demonstrate that by applying this analysis scheme on in vivo measured diffuse reflectance difference spectra, valuable information about the responses of skin tissue can be deduced and thereby the physiological status of skin can be monitored.
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