Role of mechanical signals in articular cartilage tissue regeneration: a review
by Mahvash Shokrollahlahi; Hooman Mahmoudi Aznaveh; Elahe Entekhabi; Elham Karimi Baghtifouni; Zahra Ghaffari; Masoumeh Haghbin Nazarpak; Mahdi Mirsoofian
International Journal of Nano and Biomaterials (IJNBM), Vol. 10, No. 2, 2023

Abstract: Articular cartilage (AC) is a kind of connective tissue that wraps the surfaces of long bones in diarthrodial joints and serves a vital function in the human body. Damaged cartilage has low intrinsic healing potential, leading to progressive degradation and extensive joint degeneration, a critical clinical problem in osteoarthritis treatment. Although AC tissue engineering is a potential strategy for cartilage repair, in vitro developing cartilaginous tissue that resembles the properties of native cartilage seems complicated. Controlled mechanical loadings are utilised to produce constructions in functional tissue engineering (FTE) to drive the development of a more biomechanically-competent tissue. Therefore, a thorough understanding of mechanical signals' effect on osteoarthritis paves the way for using mechanical signals to regenerate cartilages with osteoarthritis. This review describes the effects of various mechanical stimuli on AC tissue engineering. Following a brief overview of AC structure and biological function, the effects of physical stress on native and tissue-generated AC are discussed.

Online publication date: Tue, 25-Jul-2023

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Nano and Biomaterials (IJNBM):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com