The reaction of N,N-diethyl-2,3,3,3 tetrafluoropropionamide with various Grignard reagents
by S . Watanabe, T. Fujita, M . Sakamoto, O. Hosokawa, N. Ikeda
International Journal of Materials and Product Technology (IJMPT), Vol. 5, No. 3, 1990

Abstract: N,N-Diethyl2,3-difluoroalkenylamides were prepared from the reaction of N.N- diethyl-2,3,3,3 tetrafluoropropionamide (I) with various aliphatic Grignard reagents. For example, the reaction of (I) with propylmagnesium bromide gave a mixture of N,N-diethyl (Z)-2,3-difluoro-2-hexenamide (yield 34.7%) and N,N-diethyl (E)-2.3-difluoro-2-hex-enamide (yield, 11.4%). On the other hand, aryl 1,2,2,2-tetrafluoroethyl ketones were obtained from the reaction of (I) with arylmagnesium bromide. For example, the reaction of (I) with phenylmagnesium bromide gave phenyl 1,2,2,2-tetrafluoroethyl ketone (yield 46%).

Online publication date: Fri, 05-Nov-2010

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