The diversity and molecular modelling analysis of B₁₂-dependent and B₁₂-independent glycerol dehydratases
by Yuemin Liu, August A. Gallo, Rakesh K. Bajpai, Andrei Chistoserdov, Andrew T. Nelson, Leah N. Segura, Wu Xu
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 6, No. 5, 2010

Abstract: To broaden our knowledge on the diversity of glycerol dehydratases, comprehensive sequence and molecular modelling analyses of these enzymes were performed. Our sequence analysis showed that B₁₂-dependent and B₁₂-independent glycerol dehydratases are not related, suggesting that they evolved from different ancestors. Second, our study demonstrated that a gene fusion event occurred between α and β subunits of B₁₂-dependent glycerol dehydratases in several bacteria during enzyme evolution. In addition, our sequence and molecular modelling analyses revealed more B₁₂-independent glycerol dehydratases including hypothetical proteins. Furthermore, we found that some microorganisms contain both B₁₂-dependent and B₁₂-independent glycerol dehydratases in their genomes.

Online publication date: Fri, 07-Jan-2011

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