In-silico analysis and QSAR studies of tacrine hybrids with ubiquitin ligase on Alzheimer's disease
by R. Sumi Pandian, K. Hemavathi, R. Jayapradha, R. Seenivasagam
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 6, No. 6, 2010

Abstract: Ubiquitin ligase was an important protease in the pathogenesis of Alzheimer's Disease (AD). Currently, a handful of drugs were available and they are at best only able to offer some relief from symptoms. Cure for this disease is currently not available. Tacrine hybrids show inhibitory activities to the ubiquitin ligase. The three-dimensional quantitative structure–activity relationship (3D QSAR) models and in-silico studies would be useful in developing new drug leads against Alzheimer's disease. The objective of this work involves the designing of new substances, with potential inhibitory activity over AcetylCholinesterase Enzyme (AChE), using rational drug design strategies.

Online publication date: Thu, 24-Feb-2011

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Bioinformatics Research and Applications (IJBRA):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com