Receptor-based pharmacophore tool for design and development of next-generation drugs
by M. Udayakumar; Pupala Suresh Kumar; K. Hemavathi; P. Shanmugapriya; R. Seenivasagam
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 9, No. 5, 2013

Abstract: Drug discovery is an intricate process in which new drugs are designed or discovered. A pharmacophore is an essential ensemble of steric and electronic features for drug discovery, which is necessary to ensure optimal interactions with a specific target structure and to trigger its biological response. Here we present our innovative approach: the Receptor-Based Pharmacophoric Tool (RBPT), a transparent user friendly GUI sphere that generates pharmacophores using the structure of the target protein at the specified binding site. The pharmacophore generated for the specified binding site of a target can be used in virtual screening and for further studies.

Online publication date: Thu, 18-Sep-2014

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