Influence of chondroitin 4-sulphate on properties and cell behaviour of collagen hydrogel Online publication date: Thu, 23-Aug-2018
by Masrina Mohd Nadzir; Lau Sin Mun; Farah Dhaniyah Anour; Shiplu Roy Chowdhury; Mohd Fauzi Mh Busra
International Journal of Nano and Biomaterials (IJNBM), Vol. 7, No. 3, 2018
Abstract: In this research, the fabrication of collagen/chondroitin 4-sulphate (C4S) hydrogel scaffold for biomedical applications was studied. The influence of C4S content on physical, mechanical, and biological properties of scaffold were investigated. It was found that high C4S content significantly increased the swelling capacity of scaffold. Furthermore, thermal stability was higher by 5°C in the presence of C4S. Human dermal fibroblasts were cultured and bioactivity of collagen/C4S hydrogel scaffolds was assayed. Although affinity of cell attachment was reduced on hydrogel scaffold with C4S, cells were able to spread well and displayed stretched morphology. Cell viability assay was performed to evaluate cell proliferation on collagen/C4S hydrogel scaffold. The results confirmed the inclusion of C4S to collagen improved the properties of hydrogel scaffold without affecting the growth rate of cells.
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